Stephen J. GALLI, M.D.

GalliChair, Department of Pathology
Professor of Pathology and of Microbiology and Immunology,
Mary Hewett Loveless, M.D. Professor,
Co-Director, Center for Genomics and Personalized Medicine,
Stanford University School of Medicine

B.A. Degree, Harvard College
B.M.S. Degree, Dartmouth Medical School,
M.D. Degree: Harvard Medical School,
Anatomic Pathology Residency, Chief Residency, and Postdoctoral Training: Massachusetts General Hospital and Harvard Medical School, Boston, USA.

Research Interests:
• Biology of mast cells, basophils and IgE
• Allergy and Immunology, especially allergic inflammation, asthma and food allergy
• Immunotherapy of allergic disorders

Stephen J. Galli, MD, has been chair of the Department of Pathology, the Mary Hewitt Loveless, MD Professor, and a professor of pathology and of microbiology and immunology at Stanford University School of Medicine since February, 1999. In 2009 he became the Co-Director of the Stanford Center for Genomics and Personalized Medicine. Before joining Stanford, Dr. Galli served on the faculty of Harvard Medical School and was the Director of the Division of Experimental Pathology at Beth Israel Deaconess Medical Center. Dr. Galli’s research focuses on the development and function of mast cells and basophils (the major effector cells of asthma and anaphylaxis), the development of new animal models for studying the roles of these cells in health and disease, and, more recently, the mechanisms underlying desensitization and immune tolerance in subjects with allergic disorders. Dr. Galli was president of the American Society for Investigative Pathology (ASIP) (2005-2006) and has been elected to the Pluto Club (Association of University Pathologists), the Collegium Internationale Allergologicum (he is serving as president from 2010-2014), the American Society for Clinical Investigation, the Association of American Physicians, and the Institute of Medicine of the U.S. National Academies. He is also a foreign member of the Accademia Nazionale dei Lincei (National Academy of the Lynxes) in Rome, regarded as the oldest secular scientific society in the Western World. Dr. Galli received a MERIT Award from the NIAID/NIH (1995), Scientific Achievement Awards from the International Association of Allergy & Clinical Immunology (1997) and the World Allergy Organization (2011), and the Rous-Whipple Award of the ASIP (2014). He has given many named lectures, serves on several editorial boards, and has organized or co-organized many international meetings on mast cells, basophils, asthma and allergic disorders. In 2006-2007, the last year of a three year elected term, Dr. Galli was the Chair of the Advisory Board to the President and Provost of Stanford University. Among other responsibilities, the Advisory Board makes final recommendations on all faculty appointments and promotions in the tenure or research lines throughout Stanford University.

Selected publications:

  1. Nakano T, Sonoda T, Hayashi C, Yamatodani A, Kanayama Y, Yamamura T, Asai H, Yonezawa T, Kitamura Y, Galli SJ. Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J Exp Med 1985; 162:1025-43. PMID: 3897446. Reprinted as a “Pillars of Immunology” article (J Immunol 2009; 183:6863-81) with commentary: Kawakami T. A crucial door to the mast cell mystery knocked in. J Immunol 2009; 183:6861-2. PMID: 19923473
  2. Rodewald H-R, Dessing M, Dvorak AM, Galli SJ. Identification of a committed precursor for the mast cell lineage. Science 1996; 271:818-22. PMID: 8629001
  3. Lantz, CS, Boesiger J, Song CH, Mach N, Kobayashi T, Mulligan RC, Nawa Y, Dranoff G, Galli SJ. Role for interleukin-3 in mast-cell and basophil development and in parasite immunity. Nature 1998; 392:90-3. PMID: 9510253
  4. Maurer M*, Wedemeyer J* (* co-first authors), Metz M, Piliponsky AM, Weller K, Chatterjea D, Clouthier DE, Yanagisawa MM, Tsai M, Galli SJ. Mast cells promote homeostasis by limiting endothelin-1 induced toxicity. Nature 2004; 432:512-6. PubMed PMID: 15543132.
  5. Metz M, Piliponsky AM, Chen C-C, Lammel V, Åbrink M, Pejler G, Tsai M, Galli SJ. Mast cells can enhance resistance to snake and honeybee venoms. Science 2006; 103:526-30. PMID: 16873664
  6. Grimbaldeston MA, Nakae S, Kalesnikoff J, Tsai M, Galli SJ. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 2007; 8:1095-104. PMID: 17767162.
  7. Yu M, Eckart M, Morgan AA, Mukai K, Butte AJ, Tsai M, Galli SJ. Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma. J Clin Invest 2011; 121:3133-34. Epub July 9. PMID: 21737883.
  8. Akahoshi M*, Song CH* (* co-first authors), Piliponsky AM, Metz M, Guzzetta A, Åbrink M, Schlenner, S, Feyerabend TB, Rodewald HR, Pejler G, Tsai M, Galli SJ. Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venoms, and vasoactive intestinal polypeptide in mice. J Clin Invest 2011; 121:4180-91. Epub Sept 20. PMID: 21926462.
  9. Lilla JN, Chen CC, Mukai K, BenBarak MJ, Franco CB, Kalesnikoff J, Yu M, Tsai M, Piliponsky AM, Galli SJ. Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood 2011; 118:6930-8. Epub Oct 14. PMID: 22001390.
  10. Marichal T*, Starkl P* (* co-first authors), Reber LL, Kalesnikoff J, Oettgen HC, Tsai M, Metz M**, Galli SJ** (** co-corresponding authors). A beneficial role for IgE in host defense against honeybee venom. Immunity, in press. PMID: 24210352

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